Seafood Safety Enforcement Act

Seafood Safety Enforcement Act - Amends the Federal Food, Drug, and Cosmetic Act to require the Secretary of the Treasury to refuse admission to seafood that either appears to contain impermissible substances or originates from a country identified as a likely source of articles subject to refusal of admission (because of the likely presence of impermissible substances) Permits entry upon submission of acceptable evidence to the contrary.

Directs the Secretary of Health and Human Services to issue guidance when an exporter or country appears to be a source of articles subject to refused admission based on specified criteria, including the detection of substances by other importing countries.

Requires the Secretary to notify the appropriate congressional committees: (1) of all countries and exporters for which guidance was issued; and (2) before issuing a tolerance for any substance considered impermissible (the presence of which is considered grounds for refused admission).