Replace Animal Tests Act of 2025

The Replace Animal Tests Act of 2025 would modernize federal regulatory testing by requiring agencies like the FDA, EPA, USDA, and Consumer Product Safety Commission to use approved non-animal testing methods whenever they are available and scientifically valid. Currently, millions of animals are used annually in U.S. regulatory testing, often experiencing pain and confinement in tests that continue primarily due to outdated regulatory requirements rather than scientific necessity. The bill would establish a clear standard that when non-animal alternatives exist—such as organ-on-chip technologies, computational models, and human cell-based systems—companies and researchers would be prohibited from submitting animal test data to federal agencies for those applications. The bill would also require agencies to issue guidance and update regulations to reflect the acceptability of non-animal methods, and mandate annual reporting on animal use in testing. If enacted, this would align U.S. standards with practices already in place in the European Union and United Kingdom, which have required the use of scientifically satisfactory non-animal methods for decades. The bill is currently in committee and has not yet been voted on by the full House.